Sikker-Olie Research Project

This project investigates the safety of lubricant and refrigeration oils.

We are currently testing the inhalation of fresh and used engine oil. The used engine oil is black an thick compared to the fresh oil. 

We already published a review article on pulmonary exposure to mineral oils

Publications from the Sikker-Olie project

3: Hadrup N, Sørli JB, Frederiksen M, Sharma AK, Kafert-Kasting S, Schuchardt S, Bitsch A, Clausen PA, Saber AT, Vogel U, Hougaard KS. Oil mists and vapours: A review of exposure and toxicity, with dose descriptors from inhalation studies. Toxicology. 2025 Oct 16:154314. doi: 10.1016/j.tox.2025.154314. Online ahead of print. PMID: 41109551

2: Sørli JB, Shin HK, Frydendall KB, Wedebye EB, Nikolov N, Frederiksen M, Hadrup N. Toxicological potential of substances in spray-formulated degreasers and lubricants - with a literature review on asthma potentials of ammonia, maleic anhydride and methyl methacrylate. Toxicology. 2025 Oct 15:154312. doi: 10.1016/j.tox.2025.154312. PMID: 41106493

1. Sørli J, Sengupta S, Hadrup N. The correlation between lung surfactant function inhibition in vitro and the effect on breathing of mice during inhalation exposure – A study of spray-formulated engine/brake cleaners and lubricating products. Accepted for publication in Toxicology September 22, 2025.