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DoseDescriptor.com

This site collects useful links and tools for doing toxicological hazard assessment


Some quick links (for my top 6 tools) are here - Other tools can be found in the menus above


What is a dose descriptor? - it is a description of the exposure level at which substances exert toxicity (lowest-observed-adverse-effect level - LOAEL) - but it can also be the next lower exposure level (no-observed-adverse-effect level - NOAEL). The latter is often used in hazard assessment - where it is divided with assessment factors to determine the exposure level that is safe for humans (the derived no effect level) - more can be read in ECHA R8 (link below) 


Review articles where you can find dose descriptors for you risk assessment - here is a link to our papers that are almost like a ready-meal from the supermarket - ready to use!

Danish QSAR Database:

An excellent tool for getting an overview of the potential toxicity of organic substances



ECHA R8 guideline- the guideline used to make health-based recommendations for exposure limits by the National Research Centre for the Working Environment in Denmark

CLP / EU harmonised classifications (Annex VI)

The Danish Work Authorities list of occupational exposure limits(Arbejdstilsynets

grænseværdiliste):


Calculation of ppm to mg/m3 in inhalation studies

It is highly useful to be able to do this quickly as most old tox papers give ppm - and usually you want the exposure dose to be in mg/m3


XXX mg/m3 = YYY ppm x Molecular weight / 24.45


Or use the calulator located at:

EFSA default values

You need to use these values when calculating oral doses in mg/kg bw (body weight) from feed or drinking water concentrations

REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL

This is is the document explaining the terminology and of CLP harmonised classification - we often use this information in our articles 

I hope the site is useful /Niels Hadrup

The dose makes the poison (Paracelsus)